Terence McDonagh (Nicolas Cage), a homicide detective with the New Orleans Police Department, is promoted to Lieutenant after he saves a prisoner from drowning in the immediate aftermath of Hurricane Katrina. However, during his heroic act, he severely injures his back and is put on prescription pain medication. A year later, Terence – struggling with his addictions to sex, Vicodin and cocaine – finds himself in the battle to bring down drug dealer Big Fate, who is suspected of massacring an entire family of African immigrants.